Tiki, AmplifiDx & Hilltop Biosciences

At its meeting on June 8, 2021, Beacon Angels members entertained new funding proposals from the following presenters:

  • TIKI, building software to accord to social media users ownership over the data collected on them consisting of seeing it, controlling how it is used, when it is sold, and how to get paid for its sale; and
  • AmplifiDx, offering its Molecular Point-of-Care biotechnology platform in development of the DX 1000 System for infectious disease testing at the point of care; and
  • Hilltop BioSciences, a veterinary biotech offering novel therapies for inflammatory diseases such as equine asthma and canine osteoarthritis.

Members reported on Octagon Therapeutics in due diligence.

We heard updates on the funding rounds of:

  • AOA Dx,
  • GelMEDIX;
  • Cognoptix,
  • RevBio, and
  • Xeno Biosciences.

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Genomic Expressions & Octagon Therapeutics

At its monthly breakfast meeting on Tuesday, May 11th, 2021, Beacon Angels members entertained the following presenters:  

  • Octagon Therapeutics, which is developing precision immunomodulators for chronic autoimmune diseasethat specifically target immune dysregulation; and
  • Genomic Expressions, which offers OneRNA,® a disease agnostic exponentially scalable RNA analysis platform to detect disease, monitor health and design next-generation cures.

Members reported on companies in due diligence consisting of: 

  • Yarn Corporation; and
  • AOA Diagnostics.

We heard updates on the funding rounds of Cognoptix, GelMEDIX, RevBio and Xeno Biosciences.

Beacon Angels members delivered portfolio company updates.

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Carmyn and Yarn Corporation

At our monthly breakfast meeting on Tuesday, April 13th, 2021, Beacon Angels entertained new funding proposals from the following presenters:  

  • 8:45 – 9:15 AM, Carmyn, offering a Gas Station on Wheels–saving shoppers time by refueling their cars in the store parking lot; and
  • 9:30 – 10:00 AM, Yarn Corporation, developing Driftspace, the only “no code” app aimed at VR video content creators with a (non-trival) WYSIWYG editor and a real-time Web dashboard (e.g. enabling copy and paste from email into headset content).

Members reported on companies in due diligence consisting of: 

  • General Prognostics;
  • Everyday Life; and
  • AOA Diagnostics.

We heard updates on the funding rounds of GelMEDIX and RevBio, plus an update on the new funding round of Xeno Biosciences delivered by CEO Dr. David Beno:

Beacon Angels members delivered portfolio company updates.

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Thought Data & Everyday Life

At the Beacon Angels meeting on Tuesday, Feb. 9th, 2021, we entertained new funding proposals from the following presenters:  

8:45 – 9:15 AM, ThoughtData, helping enterprise businesses to detect and resolve network, application and infrastructure performance issues more effectively with a better end-user experience, and

9:30 – 10:00 AM, Everyday Life, disrupting life insurance for everyday people.

Members reported on companies in due diligence consisting of: 

  • General Prognostics

We heard updates on the funding rounds of:

  • Cognoptix bridge debt, and
  • RevBio (f/k/a Launchpad Medical), and
  • Lenoss Medical.

Beacon Angels members delivered portfolio company updates.

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Did U Remember To & General Prognostics

At its monthly meeting on Tuesday, January 12, 2021, Beacon Angels members heard the following new company presenters:

  • Did U Remember To; which has develped a combined Bluetooth Low Energy Beacon and mobile app product for providing JIT reminders, notices and alerts to consumers and businesses throughout the world, and
  • General Prognostics, which is developing a continuous blood biomarker monitoring platform to identify significant patient status changes, and to notify physician and patient, thus enabling therapy changes to avoid hospital readmissions.

We heard updates on the new funding rounds of:

  • Cognoptix bridge debt;
  • First Light Diagnostics, and
  • RevBio (f/k/a Launchpad Medical).

Beacon Angels members delivered portfolio company updates.

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VeraMorph & Dyad Medical

At our monthly breakfast meeting on January 11, 2022, Beacon Angels met in person and remotely to hear the following new company funding presentations:

  • VeraMorph: reformulating generic drugs to be more efficacious orally and co-developing new drugs through partnerships as a means to establish a diversified, low-risk portfolio of therapeutics across a wide range of disease areas; and
  • Dyad Medical: developing AI-enabled clinical applications to assist cardiologists in the interpretation of medical images.

We also considered a follow-on funding proposal from portfolio company GelMEDIX, which is developing a therapeutic, drug-eluting gel capsule for the eye.

We discussed the developing new funding round for

  • NF2 Therapeutics, which is developing a curative gene replacement therapy for the deafness, loss of mobility and devastating brain tumors caused by the rare disease NF2, and antibody-drug conjugates to treat NF2-caused meningiomas. Both therapies are eligible for the FDA’s Orphan Drug Designation.

Members will deliver due diligence reports as follows:

  • Shoreline Biome (Zainulbhai, Doscher & Smith) developing and selling patent-protected assays for more accurate and comprehensive human microbiome testing and research;
  • Jaia Robotics (Dave Smith) developing “JaiaBots,” low-cost, high-speed, micro-sized autonomous aquatic robots that work in pods of up to 20 to collect aquatic data from coastal waters up to 100m, estuaries, rivers, lakes and marshlands; and
  • Imago Rehab (Michael Pietrasiewicz, Vicky Davis), providing a virtual clinic using telerehab supplemented by a robotic glove to facilitate daily, high-repetition rehabilitation for hand-impaired stroke patients.

We also heard updates on Beacon’s portfolio companies

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2020 Meeting Archive

The following summarizes the 11 regular Beacon Angels meetings during 2020 as follows:

January 14, 2020

New funding proposals:

  • Theromics, which is developing HeatSYNC™ a new medical device technology to optimize thermal ablation (IGTA) of solid tumors or soft tissue; and
  • Testive, which uses machine learning to deliver test prep at a lower cost and at higher margins.

Members presented due diligence reports on Jetcool Technologies, Native Voice, and Navigation Science.

February 11, 2020

  • Wabbi; which is developing a platform to provide continuity of information to make security scalable between software development pipelines, so teams no longer have to choose between speed and security; and
  • IndustrialML, which is an enterprise software company that collects, cleans, and curates factory sensor and enterprise IT data, enabling industrial customers to optimize factory productivity using its proprietary machine-learning SaaS platform.

We reviewed and discuss company updates including:

  • Exit of The Search Agency,
  • Exit of Concrete Sensors, and
  • Funding follow-on rounds including of Launchpad Medical, and Xeno.

Members reported on companies in due diligence consisting of:

  • Theromics, and
  • Testive.

March 10, 2020

  • Enrich Therapeutics, which is developing a LCD-guided cell-isolation platform to enable life science research at the single-cell level; and
  • Obsidian Advanced Manufacturing, which offers a breakthrough method of printing micron-scale sensors, electromagnetics structures and radio-frequency devices directly on high-value assets.

Review and discussion of company updates including:

  • The exit of Concrete Sensors,
  • Funding a follow-on round of Xeno,
  • Funding a new round into Theromics, and
  • Completing the follow-on funding of Launchpad Medical.

April 14, 2020

Funding proposals from new companies:

  • Zeptive, which is developing a system of IOT sensors to be distributed in campuses to enable school administrators to detect banned student vaping activities; and
  • Diesel Labs, which is developing a platform to identify and analyze audience preferences as to streaming television content for media and marketing firms and companies.

Member due diligence reports:

  • Wabbi, and
  • Enrich Therapeutics.

The meeting was conducted virtually via Google Groups due to statewide efforts to retard the spread of the novel coronavirus: “15 days to stop the spread.”

May 12, 2020

Funding proposals from new companies:

  • Matthew Palmer proposed funding Orthofundamentals, which is developing an app and disposable procedural kits to simplify and help improve orthopedic care at ambulatory surgery centers (ASCs), and
  • CEO Jeff Behrens, biomolecular engineer Nasim Annabi & eye surgeon Reza Dana delivered a proposal for GelMEDIX, a new start-up to develop a light-activated biomaterial with unique properties of tissue adhesion, tunable drug elution, and biocompatibility.

Members due diligence reports on:

  • Diesel Labs, and
  • Enrich Therapeutics, and

Returning CEO Susanne Wilke gave an update on Cognoptix.

June 9, 2020

At its third virtual meeting in a row due to the Wuhan virus panic, members heard presentations from:

  • RevMedica, whose CEO Thomas Wenchell proposed funding for, which is developing a reusable robotic-assist system for handheld laparoscopic surgery, and
  • Ori Noked, Founder and CEO of ORI Imaging, which is developing an optical imaging device for early diagnosis, screening and monitoring of deep tissue pathological conditions such as pressure injuries, post-traumatic brain injury inflammation, and potentially, skin cancers.

Members heard due diligence reports on:

  • Diesel Labs
  • Enrich Therapeutics, and
  • GelMEDIX,

and heard updates on follow-on funding rounds for:

  • Theromics,
  • Cognoptix and
  • First Light Diagnostics.

July 14, 2020

Company funding proposals:

  • Ocular Technologies, which is developing a machine-learning telemedicine device platform to enable ophthalmologists to diagnose eye problems remotely and prevent blindness in up to 220 million new, remotely located patients per year; and
  • New View Surgical, whose patented, high-definition VisionPort imaging technology combines four devices–scope, camera, light source, trocar–into one easy-to-use and cost-effective device to assist surgeons in performing laparoscopic procedures.

A Member gave a due diligence report for RevMedica.

We heard updates on new or renewed funding rounds for:

  • Diesel Labs,
  • Theromics, and
  • GelMEDIX.

September 15, 2020

The new funding proposal was for Vincere Biosciences, which is developing small molecule therapeutics targeting mitochondrial quality control to cure age-related and neurodegenerative diseases.

Member due diligence reports:

  • Ocular Technologies, and
  • RevMedica.

We heard updates on new or renewed funding rounds for:

  • Diesel Labs,
  • First Light Diagnostics,
  • Theromics, and
  • GelMEDIX.

October 13, 2020

New funding proposals:  

  • 40GRID (f/k/a SOLVD), which is developing and marketing business-automation software for field-services companies; and
  • Cloud9 Online offering a “Medical Grade,” white-labeled meditation app, designed by healthcare & insurance professionals to improve chronic pain management, reduce opioids & increase patient compliance.

Member due diligence reports on: 

  • Ocular Technologies, and
  • Vincere Biosciences.

We heard updates on the new funding rounds of:

  • First Light Diagnostics (by CEO David MacDonald),
  • Datarista, and
  • RevBio (f/k/a Launchpad Medical).

November 10, 2020

New funding proposals on:

  • Amplify, a US-based additive manufacturing company specializing in the design, engineering, and manufacturing of 3D metal-printed orthopedic implants; and
  • Fit7, which is offering a patented, portable, compact, rugged mountable exercise assembly for strength & flexibility training that is lightweight and functionally designed to build total-body strength, muscular endurance, help gain flexibility, balance, boost mood, and increase energy.

Due diligence reports on:

  • 40GRID,
  • Ocular Technologies, and
  • Vincere Biosciences.

New funding rounds updates on:

  • the Cognoptix convertible note, and
  • RevBio (f/k/a Launchpad Medical).

December 9, 2020

New company presentations from:

  • Lenoss Medical, which offers a natural, biological implant solution for spinal fractures to be supplemented with new bone and for the fracture to naturally heal while eliminating all the associated risk of the current standard of care of injecting a synthetic epoxy cement; and
  • Torigen Pharmaceuticals, which is developing affordable anti-cancer biologics for dogs and cats.

Members reported on companies in due diligence consisting of: 

  • Ocular Technologies, and
  • Amplify

We heard updates on the new funding rounds of:

  • Cognoptix convertible debt;
  • First Light Diagnostics, and
  • RevBio (f/k/a Launchpad Medical).

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Vincere Biosciences

Our September meeting continued virtual by member preference.

Beacon members entertained a new funding proposal from Vincere Biosciences, which is developing small molecule therapeutics targeting mitochondrial quality control to cure age-related and neurodegenerative diseases.

Members reported on companies in due diligence consisting of:

  • Ocular Technologies, and
  • RevMedica.

We heard updates on new or renewed funding rounds for:

  • Diesel Labs,
  • First Light Diagnostics,
  • Theromics, and
  • GelMEDIX.

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2019 Meeting Archive

At its regularly scheduled meetings during 2019 Beacon Angels entertained new funding proposals from companies and due diligence reports, respectively, as follows :

January 8, 2019

  • Neurohydrate which offers a nutritional supplement to help migraine sufferers mitigate the gastrointestinal side effects of treatments, and
  • Theromics, which offers a platform for surgeons and oncologists to thermally ablate cancerous tumors, potentially cutting recurrence from an average of 30% to zero.

Due diligence: Walch High School Math.

February 12, 2019

  • WEVO, which enables marketers to evaluate and enhance digital experiences without the need for live traffic, disrupting the traditional market research and AB testing tools. and
  • Xeno Biosciences, which is developing a treatment for obesity that mimics gastric bypass surgery with an enteric-coated pill composed of components that have been shown to be safe in man. It induces the same microbiome changes caused by the surgery resulting in weight loss.

We also entertained a presentation by The Capital Network.

March 12, 2019

  • Cricduel, a fantasy cricket app (i.e. Draftkings, but for cricket) where users create fantasy cricket teams and compete with other users for cash prizes; and 
  • Canary, offering the services of an Airbnb, but for performing artists (bands and musicians) and venues such as restaurants and bars. 

Due diligence reports: Wevo and Xeno Biosciences.

April 9, 2019

  • Hilltop Biosciences, which develops and sells therapies for wound healing to large animal veterinarians; and 
    Shareity, which offers a patented social engagement platform to enable brands to create photo and video challenges whereby brands can donate money to causes as users complete the challenges. 

Due diligence: Xeno Biosciences and Canary.

Beacon portfolio company Cognoptix delivered an update on its upcoming bridge round to a larger financing, whereby the valuation is hoped to represent at least a 10X increase over Beacon’s original investment over 10 years ago.

May 14, 2019

  • Southie Autonomy, which is developing software to program robotic arms on the fly; and
  • CloudKPI, which offers predictive analytics for SaaS businesses to use business data to identify what delivers positive or negative outcomes.  

Due diligence report: Shareity.

June 11, 2019

  • U-Chu Biosensors, which is developing real-time oral health sensors for critical care; and
  • KingsCrowd, which is offering an analytics and ratings solution for online private equity markets.  

Enviro Power, a past presenter offering a micro-power generation solution, gave Beacon an update on new progress and on its current funding round.

July 9, 2019

  • Eden GeoTech, which is developing a new means of petroleum reservoir extraction using electrical stimulation in lieu of hydraulic fracturing; and 
  • Mollify, which use game techniques to incent smartphone users to create and upload their own video advertisements for client advertisers.

Due diligence reports on:

  • Enviropower which is developing a furnace-based system for point-source power generation, and
  • KingsCrowd, which seeks to become the Morningstar of the private equity markets.

September 11, 2019

  • PartRunner, which provides on-demand deliveries for trades, construction and service businesses through (1) Web and mobile apps where customers can request, track and manage deliveries and (2) a mobile app that allows drivers to match with deliveries, see routes and manage their profile business model; and 
  • Revital Therapeutics, which is developing improved, skin-substitutes to serve the $1 billion diabetic wound treatment market.

October 8, 2019

  • FastClose, which offers an on-line platform on which to close real estate sales and purchases; and 
  • ZipperAgent, offers an AI-based mobile and conversational smart assistant for real estate agents and brokers.

Due diligence: KingsCrowd.

We also heard progress reports about follow-on rounds by Datarista, Cognoptix and First Light.

We also considered follow-on funding proposals from Cognoptix and First Light Diagnostics.

November 12, 2019

  • Uneva Health, which is developing a medical device to improve asthma inhaler usage and compliance; and 
  • JETCOOL Technologies, which is developing integrated cooling solutions for the most power-dense electronics in defense, e-sports and AI processing.

Due diligence: ZipperAgent. 

December 10th, 2019

  • Native Voice, which is developing an open operating system to enable manufacturers of smart headphones, a/k/a “hearables,” to add voice applications to any device; and
  • Navigation Science, which is developing Image-guided Video-Assisted Thoracoscopic Surgery (iVATS™) technology for the minimally invasive identification of early-stage tumors and their margins, and their more precise removal from the lungs and other soft tissues.

Due diligence: Uneva Health, and Jetcool Technologies.

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Massachusetts Rated No. 1 for Innovation

WalletHub recently listed Massachusetts as first among all 50 of the United States for its potential to foster innovation, as well for having the number three healthiest economy overall so far in 2019.

Beacon Angels is pleased to be a contributor to that potential by continuing to invest in new startup companies based in Massachusetts and throughout New England and through its ongoing support of the many New England-headquartered companies in its portfolio.

 

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